n irreversible change in the tertiary structure of a protein molecule. It leads to loss of function

n irreversible change in the tertiary structure of a protein molecule. It leads to loss of function in most proteins., For proteins, a process in which a protein unravels and loses its native conformation, thereby becoming biologically inactive. For DNA, the separation of the two strands of the double helix. Denaturation occurs under extreme conditions of pH, salt concentration, and temperature.

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